CultureOne, centrifugeuse de laboratoire pour culture cellulaire à usage unique
CultureOne est une gamme de centrifugeuses de laboratoire et de production industrielle à usage unique conçues pour la culture de cellules dans le secteur biopharmaceutique. Grâce à des innovations exclusives, elles séparent avec une efficacité inégalée les produits délicats tels que les cultures cellulaires à haute densité. Découvrez tous les avantages de la gamme CultureOne.
Améliorez votre rendement avec la centrifugeuse à usage unique
- Récupération de produits avec un rendement avéré jusqu'à 99%
- Récolte de 100 à 3 000 litres de culture cellulaire
- Traitement de densités cellulaires très élevées
- Gain de temps et de productivité grâce à l'absence de nettoyage
- Economisez de 50 à 80% d'eau, d'énergie et de produits de nettoyage par rapport aux méthodes à filtres
Les centrifugeuses pour laboratoire à système "single use" CultureOne vous permettent de valoriser au mieux les produits récoltés : nos séparateurs à haute vitesse à assiettes sont plus efficaces que les autres technologies à usage unique, garantissant des rendements plus élevés allant jusqu'à 99%.
La technologie Hermetic Design est particulièrement bien adaptée aux phases délicates : elle réduit la lyse cellulaire et évite la formation de mousse, facilitant la purification en aval. Nos performances de séparation supérieures permettent d'obtenir un centrifugat clair avec une très faible teneur en solides. Cela réduit la nécessité d'une filtration secondaire, réduisant la consommation énergétique.
Les avantages de l'usage unique et connecté
Facile à installer et à retirer, le système d'assiette jetable breveté Spinsert™ supprime l'étape de nettoyage ou de stérilisation autoclave : vous changez vos lots plus rapidement, et vous réalisez des économies d'eau et d'énergie considérables.
Stérile, le bol à usage unique élimine le risque de contamination croisée entre les batchs, gage de sécurité accrue pour votre laboratoire.
Les séparateurs CultureOne s'utilisent seuls ou connectés à un système centralisé. L'automatisation et la connectivité permettent une intégrité totale des données, dans le respect de la norme 21 CFR Part 11.
Did you know?
With the Alfa Laval CultureOne range, you can scale your single-use bioprocess easily and efficiently. Our bioprocess equipment and automation solutions help you avoid data and time losses. They also meet GMP requirements for your manufacturing facility and ensure system validation, data integrity and product quality. Plus, Alfa Laval experts can support you during commissioning, validation, and qualification for GMP production. Contact us today to learn more.
Safety and quality with Spinsert™
CultureOne's performance is based on the Spinsert, a patented single-use disposable bowl and disc stack assembly – fully sterilized and ready for processing. Easy to set up and replace, it ensures fast batch changeover. It is made from recyclable polymers suited for biopharma processing.
The CultureOne range
CultureOne™ separators enhance efficiency in single-use bioprocessing, increasing product recovery and streamlining workflows from R&D to production scale.
CultureOne Primo
- Processing capacity: 240 litres/hour
- Product recovery yield: Up to 99%
CultureOne Maxi
- Processing capacity: 720 litres/hour
- Product recovery yield: Up to 99%
* Capacity figures for fed-batch mammalian cell culture materials. Actual process performance is a function of individual material characteristics.
Main facts about CultureOne™
Improving yields at every scale
The CultureOne separation platform is designed to maximize the potential of every cell culture, delivering unparalleled yields, ensuring product quality with utmost security, and minimizing additional lysis. The range ensures consistent performance throughout the transition from R&D to full-scale production, allowing for seamless scalability.
Developed with the industry to meet the most challenging demands
The CultureOne separation system was developed in close collaboration with leading biopharmaceutical manufacturers. Its unique performance has been verified in a wide range of processes to ensure it can meet ever-changing demands.
Less waste in single-use processing
With CultureOne separators, you can reduce the amount of water, chemicals, and plastic consumables required for single-use biopharma processing by 50 to 80%. The result is lower costs and added sustainability.
Are you considering single-use technology for biopharmaceutical manufacturing?
Why switch to single-use processing?
A single-use separation system secures patient safety by eliminating the risk of cross-contamination between batches. Single-use processing also enables a reduced footprint and increased flexibility, with no need for sterilization: empowering manufacturers to bring new treatments to market faster than ever before.
A better harvest with centrifugal separation
Many single-use harvesting systems cannot efficiently separate high-density cell cultures. The resulting product loss dramatically impacts the productivity and profitability of biopharmaceutical operations. CultureOne overcomes this problem by combining high-efficiency centrifugal separation with secure and convenient single-use processing.
Test, validate, and scale up your next separation solution
Whether upgrading your production line or running a proof of concept, Alfa Laval helps you choose the right separator solution with confidence. Simply get in touch to arrange a consultation and trial at one of our test centres, or to rent a unit for onsite testing.
Proven and published performance in biopharmaceutical processing
BioProcess International published a study detailing the performance of CultureOne Primo. Made in collaboration with Genentech, the study shows that the single-use centrifuge gives a recovery yield rate of up to 99% in cell harvesting and single-use bioprocessing.
Real capacity: What customers should expect from CultureOne range?
With Alfa Laval, you can safely migrate from our stainless-steel separators to our single-use separators with the CultureOne range. Whether you need a pilot plant or GMP production, we have a range that covers all your needs in single-use cell harvesting.
How can CultureOne help customers minimize their ecological footprint?
Existing single-use technologies with filters have reached limits due to increased batch sizes and cell densities. Alfa Laval's CultureOne range reduces the need for filters by up to 50-80%, offering a scalable solution that continues to minimize the ecological footprint even as demands grow. This means you can save money, resources, and waste material with the CultureOne.
How CultureOne can help customers to meet current and future market demands?
The CultureOne machine is a small, stand-alone, and easy to setup device that can help you do experiments in almost any environment. We have a great cooperation with universities and national innovation initiatives, like GeneNova.
How does CultureOne ensure data integrity and connectivity?
You can choose between standalone or centralized system, with suitable levels for monitor and control. You can enjoy open software, which ensures full accessibility to connect data historian or DCS. You can develop customized software to run on platforms. You can also achieve data integrity with complete compliance 21 CFR Part 11.
What makes CultureOne a good choice for reducing water use, energy use, and cleaning chemicals?
Traditional pharmaceutical production requires significant water and chemicals for cleanliness. Single-use systems reduce these needs but still require utility water and chemicals. The CultureOne range eliminates the need for flushing and chemicals, reducing utility fluid usage and waste material by up to 80%. This makes CultureOne an efficient and environmentally friendly choice.
What advantages can CultureOne range provide to the biopharmaceutical customer?
CultureOne can handle large batches and high cell densities. This range offers you an adaptable high-capacity solution that can process over 200 million cells per milliliter and up to 700 liters per hour. This means you can save time and money as you scale up your biopharma process.
How can Alfa Laval assist customers with validation, qualification and GMP production?
The Alfa Laval CultureOne centrifuge range can make your validation, qualification and GMP production easier. You can get Alfa Laval’s expert support, standardized commissioning tests, and mechanical training and commissioning.
How does CultureOne contribute to real scalability in biopharma processing?
When Alfa Laval customers examine harvest techniques, scalability across the product range is crucial. With CultureOne, we demonstrate this by running side-by-side trials of Primo and Maxi machines, achieving consistent results. This predictability ensures customers receive superior separation results from batch to batch, regardless of scale. CultureOne offers seamless scalability from Primo to Maxi and compatibility with traditional stainless steel separators, delivering exceptional performance at every scale of biopharmaceutical processing
How does CultureOne meet GMP production requirements?
GMP production stands for Good Manufacturing Practice, ensuring safe and reliable production of human biotherapeutics. Alfa Laval meets these stringent standards with the CultureOne system, using familiar materials and rigorously tested proprietary designs. This guarantees our customers a reliable solution for producing biotherapeutics safely and effectively.
How Does CultureOne Deliver Superior Performance with a Small Footprint?
Alfa Laval designed the CultureOne family to be compact, fitting seamlessly into typical manufacturing environments. Despite its small size, CultureOne Primo and Maxi deliver exceptional separation performance. The CultureOne range combines a small footprint with superior efficiency, ensuring outstanding separation results.
How this centrifuge enhances cell harvesting in biopharma?
Curious about the CultureOne™ separators? In this short animation, you can explore how these advanced systems support cell harvesting.